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VariantBaits™ 肿瘤全外显子捕获试剂盒

检测试剂


产品简介

VariantBaits™人全外显子肿瘤捕获试剂盒由超过900,000条LC Sciences专利技术μParaflo®微流体芯片合成的RNA探针组成,总捕获目标区域为60.54Mb,探针设计区域为62.31Mb,完整覆盖人类全外显子区域,增加COSMIC数据库中与癌症相关的787kb位点,深入剖析疾病的发病机制,应用于肿瘤相关研究与发现。

产品信息

探针稳定性


数据库覆盖


检测流程



订购信息

合作成果

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2.Porreca GJ, Zhang K, Li JB, Xie B, Austin D, Vassallo SL, LeProust EM, Peck BJ, Emig CJ, Dahl F, Gao Y, Church GM, Shendure J. (2007) Multiplex amplification of large sets of human exons. Nat Methods 4(11), 931-36.

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5.Teer JK, Bonnycastle LL, et al. (2010) Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing. Genome Res 20(10), 1420-31.

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7.Nautiyal S, Carlton VE, Lu Y, Ireland JS, Flaucher D, Moorhead M, Gray JW, Spellman P, Mindrinos M, Berg P, Faham M. (2010) High-throughput method for analyzing methylation of CpGs in targeted genomic regions. Proc Natl Acad Sci 107(28), 12587-92.

8.Myllykangas S, Buenrostro JD, et al. (2011) Efficient targeted resequencing of human germline and cancer genomes by oligonucleotide-selective sequencing. Nat Biotechnol 29, 1024-27.

9.Diep D, Plongthongkum N, Gore A, Fung H, Shoemaker R, Zhang K. (2012) Library-free methylation sequencing with bisulfite padlock probes. Nature Methods 9(3), 270-2.

10.Labrie V, Buske OJ, Oh E, Jeremian R, Ptak C, Gasiūnas G, Maleckas A, Petereit R, Žvirbliene A, Adamonis K et al.(2016) Lactase nonpersistence is directed by DNA-variation-dependent epigenetic aging. Nature Structural &Molecular Biology 23(6):566-73.

11.Zaccai F, C T, Savitzki D, Zivony-Elboum Y, Vilboux T, Fitts EC, Shoval Y, Kalfon L, Samra N, Keren Z. (2017) Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. Brain 140(2), 370-386.

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